HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 445164Generated: October 29, 2026
Dimethylamine → 1-[2-(6-dimethylamino-hexyloxy)-benzyl]-4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one
https://huagongshe.com/reaction/445164
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | 1-[2-(6-Chloro-hexyloxy)-benzyl]-4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one | HCID 60112826 | — |
| Product | 1-[2-(6-dimethylamino-hexyloxy)-benzyl]-4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one | HCID 60112813 | — |
Reaction Steps
A mixture of 50 mg (92.1 μmol) 1-[2-(6-chloro-hexyloxy)-benzyl]-4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one and 160 μl ethanolic dimethylamine solution (33%) is heated at 60° C. for 18 h. Extraction with dichloromethane and aqueous 0.1 M NaOH yields the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08476286B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-d793865cff0b4c7283f36bde35d3a51e |
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| Source note | uspto-grants-2013_07 |
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