Ammonia → HCID 60112889, compound

Participants

Reaction Steps

To an excess of phosgene dissolved in toluene are added at 0° C. 41.5 μl (0.283 mmol) N,N,N′-trimethyl-1,3-propanediamine. After 5 minutes the solvent is evaporated and the residue is dissolved in 2 ml dichloromethane. Triethylamine (79.2 μl, 0.566 mmol) and a solution of 100 mg (0.236 mmol) 1-(4-hydroxy-benzyl)-4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one in 2 ml dichloromethane are added at 0° C. After stirring for 20 h at rt aqueous ammonia and 0.1 M NaOH are added. The title compound is obtained by extraction with dichloromethane followed by reversed phase preparative HPLC.

Provenance & Evidence