Methyl iodide → HCID 60112881, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1.20 g (2 mmol) of N-{3-[4-(4-isopropyl-phenyl)-2-oxo-6-propargyloxy-2H-quinazolin-1-ylmethyl]-phenyl}-2-[4-(2-methoxy-ethyl)-piperazin-1-yl]-acetamide is treated with 4.1 ml 0.5 M LDA-solution (in THF) and 0.35 ml (2.0 mmol) HMPT at −78° C. The cooling bath is removed and stirring continued for half an hour while the solution turns slowly red. The reaction mixture is cooled down again to −78° C., 284 μl methyl iodide (2 mmol; diluted with 5 ml THF) is added. After stirring overnight at rt, the orange solution is concentrated in vacuo The yellow foamy residue is purified by chromatography (CH2Cl2/MeOH 9:1). Yield: 480 mg (13%) yellow foam.

Provenance & Evidence