Sodium Cyanate → HCID 10114316, compound

HRID 445177Notes

Reaction equation

HRID 445177 reaction equation
[CH2:1]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]#[CH:18])=[CH:11][C:10]=1[C:19]([C:21]1[CH:26]=[CH:25][C:24]([CH:27]([CH3:29])[CH3:28])=[C:23]([Cl:30])[CH:22]=1)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O-:31][C:32]#[N:33].[Na+]>>[CH2:1]([N:8]1[C:9]2[C:10](=[CH:11][C:12]([O:15][CH2:16][C:17]#[CH:18])=[CH:13][CH:14]=2)[C:19]([C:21]2[CH:26]=[CH:25][C:24]([CH:27]([CH3:29])[CH3:28])=[C:23]([Cl:30])[CH:22]=2)=[N:33][C:32]1=[O:31])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 517096Sodium CyanateHCID 60112860HCID 60112860, compound

Product 1

HCID 10114316HCID 10114316, compound

Procedure

The title compound is prepared from (2-benzylamino-5-prop-2-ynyloxy-phenyl)-(3-chloro-4-isopropylphenyl)-methanone (hydrochloric acid salt) by cyclisation with sodium cyanate analogously to the method described for the preparation of example 62.

Workup

  1. customdescribed for the preparation of example 62

Sources & evidence

ORD record
ord-177aafc19d164a7d9ad16104d626b96f
Source dataset
uspto-grants-2013_07
Patent number
US08476286B2

Reaction notes

Loading…