Phenol → HCID 60112791, compound

Participants

Reaction Steps

216 mg (2.30 mmol) phenol and 11 mg (0.44 mmol) are dissolved in 2 ml t-butanol and the resulting solution is stirred for 3 h at rt. After that time 80 mg (0.23 mmol) 2-chloro-4-(4-isopropyl-phenyl)-6,7-dimethoxy-quinazoline is added and the solution is stirred at 85° C. overnight. The reaction mixture is diluted with ether and extracted with brine. The organic layer is dried and evaporated. After chromatography (hexane/ethyl acetate the product is obtained as yellow solid.

Provenance & Evidence