反应详情

A solution of 100 mg (0.228 mmol) 1-(2-hydroxy-2-phenyl-ethyl)-4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one in 1 ml acetic anhydride is heated at 100° C. for 18 h. The reaction mixture is poured onto 1 M aqueous NaOH and extracted with ether. The product is purified by preparative reversed phase HPLC.

1. extractionextracted with ether
2. customThe product is purified by preparative reversed phase HPLC