反应详情

Add thionyl chloride (0.35 mL, 4.80 mmol) to a solution of 2-bromothiophene-3-carboxylic acid (500 mg, 2.41 mmol) and toluene (20 mL) with stirring. Purge the reaction vessel with nitrogen. Heat the mixture to reflux and stir for 3 hours. Concentrate the mixture to obtain the title compound (540 mg, 2.41 mmol). Use compound in next procedure without further purification.

1. customPurge the reaction vessel with nitrogen
2. temperatureHeat the mixture
3. temperatureto reflux
4. stirringstir for 3 hours
5. concentrationConcentrate the mixture