Ammonia → 2-Bromothiophene-3-carboxamide

HRID 445216Notes

Reaction equation

HRID 445216 reaction equation
[Br:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7](Cl)=[O:8].[NH3:10]>>[Br:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]([NH2:10])=[O:8]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 201947092-Bromothiophene-3-carbonyl chloride

Product 1

HCID 189381422-Bromothiophene-3-carboxamideYield 90.8%

Procedure

Add 2-bromothiophene-3-carbonyl chloride (540 mg, 2.39 mmol) to a solution of aqueous ammonia (25%, 3 mL, 17.44 mmol) with stirring. Stir the mixture for 30 minutes. Concentrate the mixture. Collect the resulting precipitate via filtration and wash the solids with water. Dry the white precipitate in vacuo to obtain the title compound (450 mg, 2.17 mmol).

Workup

  1. stirringStir the mixture for 30 minutes
  2. concentrationConcentrate the mixture
  3. customCollect the resulting precipitate
  4. filtrationvia filtration
  5. washwash the solids with water
  6. customDry the white precipitate in vacuo

Sources & evidence

ORD record
ord-16af517cd9484e61b351f63c30bda4fd
Source dataset
uspto-grants-2013_07
Patent number
US08476300B2

Reaction notes

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