HCID 59536335, compound → HCID 42634731, compound

HRID 445243Notes

Reaction equation

HRID 445243 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11][N:10]2[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:5][CH:4]=1>CCO.[Pd]>[F:24][C:2]([F:1])([F:25])[C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:12][CH2:11][N:10]2[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:7][CH:8]=1

Participants

4

Reactant 1

HCID 59536335HCID 59536335, compound

Product 1

HCID 42634731HCID 42634731, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of ethyl 1-(4-(trifluoromethyl)phenyl)isoquinoline-2(1H)-carboxylate (2.0 g, 5.7 mmol) in EtOH (20 mL) was stirred with 10% Pd/C (0.6 g, 5.7 mmol) under a hydrogen atmosphere at RT for 2 h. The reaction mixture was filtered through a celite pad and the filtrate was concentrated in vacuo to provide the title compound as colorless oil. MS (ESI pos. ion) m/z: 350 (M+1).

Workup

  1. filtrationThe reaction mixture was filtered through a celite pad
  2. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-8dc5b37684ff4073af32e410160d4082
Source dataset
uspto-grants-2013_07
Patent number
US08476297B2

Reaction notes

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