Methanol → HCID 42634733, compound

Participants

Reaction Steps

To a solution of 1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline (500 mg, 1.80 mmol) and DIEA (0.314 mL, 1.80 mmol) in DCM (9 mL) was added phenyl isocyanate (0.196 mL, 1.80 mmol). The resulting mixture was stirred at RT for 3 h. Then, MeOH (50 mL) was added and the mixture was concentrated. The residue was purified by silica gel flash column chromatography (0%-50% EtOAc/hexane) to give the title compound as a light yellow solid. The solid was then washed with MeOH (3×20 mL) to give 440 mg of the title compound as a white solid. MS (ESI, positive ion) m/z: 397 (M+H).

Provenance & Evidence