HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl isocyanate → HCID 59536411, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl isocyanate | HCID 76639 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-(4-(Trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline | HCID 16640696 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 59536411 | HCID 59536411 | — |
Reaction Steps
To a solution of 1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline (100 mg, 0.36 mmol, example 9 (step 3) and DIEA (62.8 μL, 0.36 mmol) in DCM (2 mL) was added benzyl isocyanate (44.2 μL, 0.36 mmol). The resulting mixture was reacted under the same conditions as described for example 10 to give the title compound as a white solid. MS (ESI, positive ion) m/z: 411 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476297B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-221d0fbd6352487b96a079fad78e319f |
| Source note | uspto-grants-2013_07 |