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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 445259Generated: October 30, 2026

Benzyl isocyanate → HCID 59536411, compound

https://huagongshe.com/reaction/445259

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzyl isocyanateHCID 76639—
ReactantDiisopropylethylamineHCID 81531—
Reactant1-(4-(Trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinolineHCID 16640696—
SolventDichloromethaneHCID 6344—
ProductHCID 59536411HCID 59536411—

Reaction Steps

To a solution of 1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline (100 mg, 0.36 mmol, example 9 (step 3) and DIEA (62.8 μL, 0.36 mmol) in DCM (2 mL) was added benzyl isocyanate (44.2 μL, 0.36 mmol). The resulting mixture was reacted under the same conditions as described for example 10 to give the title compound as a white solid. MS (ESI, positive ion) m/z: 411 (M+H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08476297B2
Source datasetuspto-grants-2013_07
ORD IDord-221d0fbd6352487b96a079fad78e319f
Source noteuspto-grants-2013_07