Acetic Acid → HCID 59536329, compound

Participants

Reaction Steps

A solution of 1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline (0.5 g, 2 mmol) (Example 9, step 3) in dichloromethane (10 mL) was treated with pyridine (1.4 mL, 17 mmol), triethylamine (0.5 mL, 4 mmol), potassium cyanate (0.3 g, 3 mmol), glacial acetic acid (1.00 mL, 17 mmol) and the resulting suspension was stirred at RT for 12 h. The reaction mixture was concentrated to a gummy residue which was taken up in dichloromethane (75 mL), washed with brine (35 mL), dried over anhydrous sodium sulfate, removed dichloromethane, and dried under high vacuum to yield (4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide as a white solid. MS (ESI pos. ion) m/z: 321 (M+1).

Provenance & Evidence