反应详情

温度

110 °C

A 250-mL round-bottomed flask was charged with N-(2-phenylpropyl)-4-(trifluoromethyl)benzamide (5.19 g, 16.9 mmol), phosphorous pentoxide (4.8 g, 33.8 mmol) and toluene (75 mL). The reaction mixture was heated at 110° C. overnight and allowed to cool down to RT. Then it was poured over ice-water and neutralized with NaOH (10%). The organic phase was separated and the aqueous phase was extracted several times with EtOAc. The combined organics were washed with satd. NaHCO3, water, brine and dried over Na2SO4. The solvent was removed under vacuum and the product used without further purification.

1. temperatureto cool down to RT
2. customThe organic phase was separated
3. extractionthe aqueous phase was extracted several times with EtOAc
4. washThe combined organics were washed with satd
5. dry with materialNaHCO3, water, brine and dried over Na2SO4
6. customThe solvent was removed under vacuum
7. customthe product used without further purification