Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → HCID 59536363, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| 반응물 | 4,4-Difluorocyclohexan-1-amine hydrochloride | HCID 23150669 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 59536363 | HCID 59536363 | — |
반응 단계
To a solution of 4,4-difluorocyclohexanamine hydrochloride (Matrix scientific, 250 mg, 1.45 mmol) in DCM (5 mL) was added 4-nitrophenyl chloroformate (367 mg, 1.82 mmol) and DIEA (507 μl, 0.29 mmol). The resulting mixture was then stirred at RT for 16 h. Then, MeOH (2 mL) was added and the solvents were removed. The residue was purified by silica gel flash column chromatography (0%-100% EtOAc/hexane) to give the title compound as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08476297B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-00c2f84f8c2b42dca18083329f211cb5 |
| 출처 메모 | uspto-grants-2013_07 |