Isopropyl isocyanate → HCID 59536260, compound

Participants

Reaction Steps

To a stirred solution of 1-(3-fluoro-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydro-isoquinoline (0.1020 g, 0.345 mmol) in 3 mL of DCM, isopropyl isocyanate (0.0400 mL, 0.407 mmol) was added. The solution was stirred for 1 h. Solvent was evaporated and the residue was purified by silica gel chromatography (0-50% EtOAc in hexanes) then again with 10-40% EtOAc in hexanes to afford the title compound as a white solid. MS (ESI pos. ion) m/z: 381.1 (M+1). 1H NMR (300 MHz, CHLOROFORM-d) δ ppm 7.48 (t, J=7.75 Hz, 1H) 7.19-7.32 (m, 2H) 7.01-7.14 (m, 2H) 6.55 (s, 1H) 4.30 (s, 1H) 3.98-4.13 (m, 1H) 3.38-3.63 (m, 2H) 2.69-2.98 (m, 2H) 1.13-1.25 (m, 6H).

Provenance & Evidence