4-Fluorophenyl isocyanate → HCID 59536273, compound

Participants

Reaction Steps

To a stirred solution of 1-(3-fluoro-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydro-isoquinoline (0.0845 g, 0.286 mmol, Example 71 Step 3) in 3 mL of DCM, 4-fluorophenyl isocyanate (0.0358 mL, 0.315 mmol) was added. The solution was stirred for 1 h. Solvent was evaporated and the residue was purified by silica gel chromatography (0-50% EtOAc in hexanes) to yield the title compound as a white solid. MS (ESI pos. ion) m/z: 433.1 (M+1). 1H NMR (300 MHz, CHLOROFORM-d) δ ppm 7.51 (t, J=7.75 Hz, 1H) 7.22-7.39 (m, 6H) 7.06-7.19 (m, 2H) 6.96-7.05 (m, 2H) 6.63 (s, 1H) 6.45 (s, 1H) 3.59-3.81 (m, 2H) 2.76-3.08 (m, 2H).

Provenance & Evidence