4-Fluorophenyl isocyanate → HCID 59536350, compound

Participants

Reaction Steps

To a solution of 4-((1R,3S)-3-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)benzoic acid (22 mg, 82 μmol) in CH2Cl2 (0.5 mL) at RT was added 1-fluoro-4-isocyanatobenzene (28 mg, 206 μmol). The reaction was stirred 5 h and directly purified by HPLC to give 4-((1R,3S)-2-((4-fluorophenyl)carbamoyl)-3-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)benzoic acid as a white solid. MS (ESI pos. ion) m/z: 405 (M+1).

Provenance & Evidence