Phenethylamine → HCID 706676, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of phenylethylamine (14.0 g, 14.6 mL, 115.5 mmol) and diea (20.1 mL, 115.5 mmol) in DCM (500 mL) at 0° C. was added 4-(trifluoromethyl)benzoyl chloride (17.2 mL, 115.5 mmol) dropwise. After addition, the reaction mixture was then stirred at 0° C. and warmed up itself to RT overnight. An off-white solid precipitation was observed. The off-white solid was collected by filtration. The solid was then washed with DCM (2×50 mL), and dried under vacuum to give 31.8 g of the title compound as a white solid. MS (ESI, positive ion) m/z: 294 (M+H).

Provenance & Evidence