Butyl isocyanate → HCID 59536326, compound

Participants

Reaction Steps

To a solution of (R)-1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline (198 mg, 714 μmol, Example 87, Step 3) in DCM (2.0 mL) was added n-butyl isocyanate (88 μL, 785 μmol). The resulting mixture was then stirred at RT for overnight. Then, the solvent was removed and the residue was mixed with silica gel. The solid mixture was the purified by silica gel flash column chromatography using ISCO instrument (solid loading, 0%-400% EtOAc/hexane) to give the title compound as a colorless solid. MS (ESI, positive ion) m/z: 377 (M+H).

Provenance & Evidence