Diisopropylethylamine → HCID 42634921, compound

Participants

Reaction Steps

A mixture of 1-(trifluoromethyl)cyclopropane carboxylic acid (0.36 g, 2.3 mmol), DIEA (0.41 mL, 2.3 mmol), and diphenylphosphoryl azide (0.51 mL, 2.3 mmol) in p-dioxane (8 mL) was stirred at RT for 1 h. (R)-1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline (0.500 g, 1.8 mmol) was added and the mixture was heated to reflux for 16 h. The mixture was cooled, concentrated and purified by ISCO (0-40% EtOAc/hexanes) to give the title compound. MS (ESI, positive ion) m/z: 429 (M+1).

Provenance & Evidence