Cyclopropylamine → HCID 59536381, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of triphosgene (0.05 mL, 0.4 mmol) in DCM (1 mL) at 0° C. was added a mixture of (R)-1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline (0.200 g, 0.7 mmol) and diisopropylethylamine (0.1 mL, 0.8 mmol) in DCM (1 mL). After stirring at 0° C. in 30 min, cyclopropylamine (0.04 mL, 0.7 mmol) was added and the mixture was continued to stir at RT for 24 h. H2O was added and layers were separated. The organic extracts were dried over MgSO4, concentrated and purified by ISCO (20% EtOAc/hexanes) to give the white solid title compound. MS (ESI, positive ion) m/z: 361 (M+1).

Provenance & Evidence