HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 59536296, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4,4-Difluorocyclohexanecarboxylic acid | HCID 2779136 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | (R)-1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline | HCID 28293305 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59536296 | HCID 59536296 | — |
Reaction Steps
To a stirred mixture of (R)-1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline (0.205 g, 0.74 mmol), DIEA (0.14 mL, 0.81 mmol), and 4,4-difluoro-cyclohexanecarboxylic acid (0.13 g, 0.81 mmol) in DMF (4 mL) was added HATU (0.31 g, 0.81 mmol). The reaction mixture was continued to stir for 2 h, quenched with H2O, and extracted with DCM (3×). The organic extracts were dried over Na2SO4, concentrated and purified by ISCO (20% EtOAc/hexanes) to give the white solid. MS (ESI, positive ion) m/z: 424 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476297B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-b35ace90e18c4edb9b1145d0e426128b |
| Source note | uspto-grants-2013_07 |