Isobutylamine → HCID 59536365, compound

Participants

Reaction Steps

To a stirred mixture of (R)-1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline (0.100 g, 0.36 mmol) and DIEA (0.082 mL, 0.47 mmol) in THF (2 mL) was added 4-nitrophenyl chloroformate (0.080 g, 0.40 mmol). The reaction mixture was stirred for 30 min, 2-methylpropan-1-amine (0.036 mL, 0.36 mmol) was added and stirring was continued for 14 h, then heated at reflux for 24 h, cooled, taken up in H2O, extracted with EtOAc (3×), dried over MgSO4, concentrated and purified by ISCO (20% EtOAc/hexanes) to give the title compound. MS (ESI, positive ion) m/z: 377 (M+1).

Provenance & Evidence