4-Fluorophenyl isocyanate → 5-bromo-N-(4-fluorophenyl)-1-(4-(trifluoromethyl)-phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

Participants

Reaction Steps

To a 50 mL round-bottomed flask was added 5-bromo-1-(4-(trifluoromethyl)-phenyl)-1,2,3,4-tetrahydroisoquinoline (44 mg, 124 μmol, from step 3, example 146), CH2Cl2 (2 mL), 4-fluorophenyl isocyanate (17 mg, 124 μmol, Aldrich). The reaction mixture was stirred at RT for 1 h. The solvent was removed in vacuo and the residue was purified by silica gel chromatography, eluting with 50% EtOAc/hexanes to give 5-bromo-N-(4-fluorophenyl)-1-(4-(trifluoromethyl)-phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide. MS (ESI pos. ion) m/z: 493 (M+1).

Provenance & Evidence