1,1'-Carbonyldiimidazole → HCID 59536332, compound

Participants

Reaction Conditions

Reaction Steps

To a 50 mL round-bottomed flask was added 4-fluoro-N-(2-methoxyethyl)-benzenamine (512 mg, 3026 μmol, from step 1), 1,1′-carbonyldiimidazole (736 mg, 4539 μmol, Aldrich), THF (2 mL). The reaction mixture was stirred at 80° C. for 28 h. The solvent was removed in vacuo and the residue was purified by silica gel chromatography, eluting with 80% EtOAc/hexanes to give N-(4-fluoro-phenyl)-N-(2-methoxyethyl)-1H-imidazole-1-carboxamide. MS (ESI pos. ion) m/z: 264 (M+1).

Provenance & Evidence