(R)-1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline → (R)-N-(2-(1,3-dioxoisoindolin-2-yl)ethyl)-N-(4-fluorophenyl)-1-(4-(trifluoromethyl)-phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

Participants

Reaction Conditions

Reaction Steps

To a 50 mL round-bottomed flask was added (R)-1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline (80 mg, 290 μmol), 1-((2-(1,3-dioxoisoindolin-2-yl)ethyl)(4-fluorophenyl)carbamoyl)-3-methyl-1H-imidazol-3-ium iodide (151 mg, 290 μmol, from step 3), CH2Cl2 (2 mL). The reaction mixture was stirred at 40° C. for 48 h. The solvent was removed in vacuo and the residue was purified by silica gel chromatography, eluting with 30% EtOAc/hexanes to give (R)—N-(2-(1,3-dioxoisoindolin-2-yl)ethyl)-N-(4-fluorophenyl)-1-(4-(trifluoromethyl)-phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide. MS (ESI pos. ion) m/z: 588 (M+1).

Provenance & Evidence