HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 445387Generated: October 29, 2026
Hydrochloric Acid → HCID 3776480, compound
https://huagongshe.com/reaction/445387
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-[1-(1H-Indol-3-yl)-3,4-dihydroisoquinolin-2(1H)-yl]ethan-1-one | HCID 56654904 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 3776480 | HCID 3776480 | — |
Reaction Steps
To a solution 1-(1-(1H-indol-3-yl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone (50 mg, 172 μmol in MeOH (1.0 mL) was added 5 M HCl (1.0 mL, 5000 μmol). The reaction was heated to 100° C. under microwave 30 min. The reaction was concentrated to give 1-(1H-indol-3-yl)-1,2,3,4-tetrahydroisoquinoline, which was used in the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08476297B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-3baedec6cfdd4acc8a2b9c50e2f9af50 |
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| Source note | uspto-grants-2013_07 |
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