反应详情

A solution of 7-phenylheptan-1-ol (5 g) in CH2Cl2 (25 mL) was added to a suspension of 1,1,1-tris(acetyloxy)1,1-dihydro-1,2-benziodoxol-3-(1H)-one (Dess-Martin periodinane) in CH2Cl2 (25 mL) dropwise with ice-bath cooling. The cooling bath was removed after addition was complete and the resulting mixture was stirred at room temperature for 3 h. After addition of a solution of Na2S2O3 (44 g) in saturated NaHCO3, (35 mL), the resulting mixture was stirred for 45 min and the layers were separated. The aqueous layer was extracted twice with CH2Cl2, and the combined organic phases were washed with water, dried over Na2SO4 and concentrated to yield 7-phenylheptanal as an oil, which was used in the next step without further purification.

1. temperaturecooling
2. customThe cooling bath was removed
3. additionafter addition
4. additionAfter addition of a solution of Na2S2O3 (44 g) in saturated NaHCO3, (35 mL)
5. stirringthe resulting mixture was stirred for 45 min
6. customthe layers were separated
7. extractionThe aqueous layer was extracted twice with CH2Cl2
8. washthe combined organic phases were washed with water
9. dry with materialdried over Na2SO4
10. concentrationconcentrated