Ethyl Acetate → HCID 66822316, compound

Participants

Reaction Steps

A two-phase solution of the 2-hydroxy-8-phenyloctanimidate, ethyl acetate (50 mL), and water (50 mL) was stirred overnight. The layers were separated and the organic phase was dried (Na2SO4), filtered and concentrated to yield methyl 2-hydroxy-8-phenyloctanoate as an oil. The oil was dissolved in 9:1 dioxane-water (50 mL) containing LiOH (1.7 g). After 2 h of stirring, the mixture was acidified with 2N HCL to pH˜3. The resulting mixture was extracted twice with EtOAc and the combined organic phases were washed with brine, dried (Na2SO4), filtered and concentrated to yield 2-hydroxy-8-phenyloctanoic acid as a solid.

Provenance & Evidence