HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl((5-(4-(benzyloxy)phenyl)-1,3,4-thiadiazol-2-yl)methyl)carbamate → 4-(5-(Aminomethyl)-1,3,4-thiadiazol-2-yl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl((5-(4-(benzyloxy)phenyl)-1,3,4-thiadiazol-2-yl)methyl)carbamate | HCID 123333842 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 4-(5-(Aminomethyl)-1,3,4-thiadiazol-2-yl)phenol | HCID 136340686 | — |
Reaction Steps
A solution of benzyl((5-(4-(benzyloxy)phenyl)-1,3,4-thiadiazol-2-yl)methyl)carbamate (7.4 g, 17.1 mmol) in 33% HBr in acetic acid (100 mL) and was stirred for 2 h. The resulting mixture was diluted with diethyl ether and the precipitate was collected and washed with diethyl ether to yield 4-(5-(aminomethyl)-1,3,4-thiadiazol-2-yl)phenol (MS m/z=408 MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476302B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-62ecadd3cac4401d8591de3ba42f70fe |
| Source note | uspto-grants-2013_07 |