4-(4-Amino-2-fluoro-phenoxy)-6,7-dimethoxy-quinolin-2-ylamine → [4-(4-Amino-2-fluoro-phenoxy)-6,7-dimethoxy-quinolin-2-yl]-methyl-amine

HRID 445519Notes

Reaction equation

HRID 445519 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[C:8]([NH:15][CH3:16])[CH:7]=[C:6]2[OH:17].[NH2:18][C:19]1[CH:40]=[CH:39][C:22](OC2C3C(=CC(OC)=C(OC)C=3)N=C(N)C=2)=[C:21]([F:41])[CH:20]=1>>[NH2:18][C:19]1[CH:40]=[CH:39][C:22]([O:17][C:6]2[C:5]3[C:10](=[CH:11][C:12]([O:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=3)[N:9]=[C:8]([NH:15][CH3:16])[CH:7]=2)=[C:21]([F:41])[CH:20]=1

Participants

3

Reactant 2

HCID 578103564-(4-Amino-2-fluoro-phenoxy)-6,7-dimethoxy-quinolin-2-ylamineHCID 178482268HCID 178482268, compound

Product 1

HCID 57810112[4-(4-Amino-2-fluoro-phenoxy)-6,7-dimethoxy-quinolin-2-yl]-methyl-amine

Procedure

[4-(4-Amino-2-fluoro-phenoxy)-6,7-dimethoxy-quinolin-2-yl]-methyl-amine was synthesized from 6,7-dimethoxy-2-methylamino-quinolin-4-ol in a similar manner as 4-(4-Amino-2-fluoro-phenoxy)-6,7-dimethoxy-quinolin-2-ylamine, and isolated as a yellow oil (58% yield). LCMS: m/z 330 (M+H)+.

Sources & evidence

ORD record
ord-18c42b0b1fd5426f8e6bb8d832544d9b
Source dataset
uspto-grants-2013_07
Patent number
US08476298B2

Reaction notes

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