Comenic acid → Kojic Acid

HRID 445530Notes

Reaction equation

HRID 445530 reaction equation
[CH:1]1[C:6](=[O:7])[C:5]([OH:8])=[CH:4][O:3][C:2]=1[C:9]([OH:11])=[O:10]>O>[CH:1]1[C:6](=[O:7])[C:5]([OH:8])=[CH:4][O:3][C:2]=1[C:9]([OH:11])=[O:10].[CH:1]1[C:6](=[O:7])[C:5]([OH:8])=[CH:4][O:3][C:2]=1[CH2:9][OH:10]

Participants

4

Reactant 1

HCID 68139Comenic acid3×

Product 2

HCID 3840Kojic AcidHCID 68139Comenic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Comenic acid was found to be an excellent representative of the gamma-pyrone group in use for the purposes of the present invention. 5-hydroxy-4-oxo-4H-pyran-2-carbon acid, or comenic acid, exists in the form of yellowish crystals, has a melting point of about 270° C., and has a molecular mass equal to 156.095 (C6H4O5). Comenic acid is moderately water- and alcohol-soluble and practically insoluble in nonpolar organic solvents. Comenic acid is produced from kojic acid with good yield. Comenic acid is one of the ingredients of a widely used antibacterial medicinal preparation sold in Russia, Baliz-2.

Sources & evidence

ORD record
ord-45d2c5f93000486da8aa4ad653aba0cd
Source dataset
uspto-grants-2013_07
Patent number
US08476314B2

Reaction notes

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