(6-Methoxypyridin-3-yl)boronic acid → HCID 49835132, compound

Participants

Reaction Steps

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(2,4-dimethyl-2H-pyrazol-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate I, 40 mg, 0.106 mmol) and 2-methoxy-5-pyridineboronic acid (Aldrich, Buchs, Switzerland, 20 mg, 0.131 mmol) to give the title compound as a white solid. (HPLC: tR 2.69 min (Method A); M+H=401 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 9.03 (s, 1H), 8.27-8.21 (m, 1H), 8.16-8.09 (m, 1H), 7.96-7.89 (m, 1H), 7.84-7.77 (m, 1H), 7.65 (s, 1H), 7.00-6.88 (m, 2H), 3.88 (s, 3H), 3.61 (s, 6H), 1.82 (s, 3H))

Provenance & Evidence