2-Fluoropyridine-3-boronic acid → HCID 59620032, compound

Participants

Reaction Steps

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate C, 50 mg, 0.135 mmol) and 2-fluoropyridine-3-boronic acid (Aldrich, Buchs, Switzerland, 25 mg, 0.179 mmol) to give the title compound as a red solid. (HPLC: tR 2.57 min (Method A); M+H=389 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 9.07 (s, 1H), 8.27-8.22 (m, 1H), 8.18-8.13 (m, 1H), 8.06-7.99 (m, 1H), 7.89-7.83 (m, 1H), 7.51-7.45 (m, 1H), 7.24-7.20 (m, 1H), 6.45 (s, 1H), 3.60 (s, 3H), 3.55 (s, 3H), 2.24 (s, 3H))

Provenance & Evidence