5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo(2,3-b)pyridine → HCID 49835422, compound

Participants

Reaction Steps

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A, 39 mg, 0.105 mmol) and 7-azaindole-5-boronic acid pinacol ester (ABCR, Karlsruhe, Germany, 31 mg, 0.127 mmol) to give the title compound as a white solid. (HPLC: tR 2.35 min (Method A); M+H=410 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 11.75 (s, br, 1H), 8.95 (s, 1H), 8.38-8.28 (m, 1H), 8.22-8.15 (m, 1H), 8.13-8.03 (m, 2H), 8.01-7.95 (m, 1H), 7.59-7.51 (m, 2H), 6.55-6.47 (m, 1H), 3.93 (s, 3H), 3.58 (s, 3H), 1.97 (s, 3H))

Provenance & Evidence