4-(Methylcarbamoyl)benzeneboronic acid → HCID 59619743, compound

Participants

Reaction Steps

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A, 48 mg, 0.129 mmol) and 4-(N-methylaminocarbonyl)phenylboronic acid (ABCR, Karlsruhe, Germany, 27 mg, 0.153 mmol) to give the title compound as a white solid. (HPLC: tR 2.40 min (Method A); M+H=427 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 8.97 (s, 1H), 8.54-8.48 (m, 1H), 8.19-8.15 (m, 1H), 8.13-8.07 (m, 1H), 7.98-7.89 (m, 3H), 7.61-7.53 (m, 3H), 3.94 (s, 3H), 3.57 (s, 3H), 2.79 (d, 3H), 1.95 (s, 3H))

Provenance & Evidence