(4-(1H-Pyrazol-1-yl)phenyl)boronic acid → 1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(4-pyrazol-1-yl-phenyl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one

Beteiligte Stoffe

Reaktionsschritte

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A, 40 mg, 0.106 mmol) and 4-(1H-pyrazol-1-yl)phenylboronic acid (Combi-Blocks, San Diego, USA, 24 mg, 0.126 mmol) to give the title compound as a white solid. (HPLC: tR 2.79 min (Method A); M+H=436 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 8.96 (s, 1H), 8.60-8.56 (m, 1H), 8.19-8.15 (m, 1H), 8.13-8.07 (m, 1H), 7.99-7.93 (m, 3H), 7.80-7.75 (m, 1H), 7.63-7.56 (m, 3H), 6.59-6.53 (m, 1H), 3.95 (s, 31-1), 3.57 (s, 3H), 1.97 (s, 3H))

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