2-Ethoxypyrimidine-5-boronic acid → 1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(2-ethoxy-pyrimidin-5-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one

Participants

Reaction Steps

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A, 40 mg, 0.106 mmol) and 2-ethoxypyrimidine-5-boronic acid (Synthonix, Wake Forest, USA, 22 mg, 0.130 mmol) to give the title compound as a white solid. (HPLC: tR 2.51 min (Method A); M+H=416 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 8.98 (s, 1H), 8.73-8.67 (m, 2H), 8.16-8.09 (m, 2H), 7.98-7.91 (m, 1H), 7.51-7.46 (m, 1H), 4.39 (q, 2H), 3.89 (s, 3H), 3.57 (s, 3H), 1.96 (s, 3H), 1.35 (t, 3H))

Provenance & Evidence