3-(Methoxymethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine → HCID 59619773, compound

Participants

Reaction Steps

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A, 40 mg, 0.107 mmol) and 5-(methoxymethyl)pyridine-3-boronic acid pinacol ester (PepTeck, Burlington, USA, 32 mg, 0.128 mmol) to give the title compound as a white solid. (HPLC: tR 2.08 min (Method A); M+H=415 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 9.01 (s, 1H), 8.70-8.67 (m, 1H), 8.56-8.54 (m, 1H), 8.19-8.13 (m, 2H), 8.02-7.98 (m, 1H), 7.82-7.80 (m, 1H), 7.62-7.59 (m, 1H), 4.53 (s, 2H), 3.94 (s, 3H), 3.60 (s, 3H), 3.37 (s, 3H), 1.97 (s, 3H))

Provenance & Evidence