3-Ethoxybenzeneboronic acid → HCID 59620030, compound

Participants

Reaction Steps

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A, 40 mg, 0.107 mmol) and 3-ethoxyphenylboronic acid (Aldrich, Buchs, Switzerland, 21.4 mg, 0.129 mmol) to give the title compound as a white solid. (HPLC: tR 2.84 min (Method A); M+H=414 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 8.96 (s, 1H), 8.16 (s, 1H), 8.09-8.06 (m, 1H), 7.94-7.91 (m, 1H), 7.57-7.59 (m, 1H), 7.39-7.35 (m, 1H), 7.12-6.92 (m, 3H), 4.09 (q, 2H), 3.92 (s, 3H), 3.58 (s, 3H), 1.96 (s, 3H), 1.37 (t, 3H))

Provenance & Evidence