反应详情

To a solution of 5-bromo-2-methyl-pyridin-3-ylamine (Stage 75.1.4, 573 mg, 3.06 mmol) in pyridine (6 ml) was added dropwise methanesulfonyl chloride (Aldrich, Buchs, Switzerland, 0.286 ml, 3.68 mmol). The reaction mixture was stirred for 18 h at rt then are added methanesulfonyl chloride (0.03 ml, 0.39 mmol). The reaction mixture was stirred 4 h at rt before being evaporated to dryness. The residue was dissolved in EtOAc and washed with saturated aqueous NaHCO3 and brine, dried over Na2SO4, filtered and evaporated. The crude product was dry loaded on silica gel and purified by MPLC (DCM/MeOH 0%-5%) to give the title compound as a pinkish solid. (HPLC: tR 2.05 min (Method A); M+H=265, 267 MS-ES).

1. stirringThe reaction mixture was stirred 4 h at rt
2. custombefore being evaporated to dryness
3. dissolutionThe residue was dissolved in EtOAc
4. washwashed with saturated aqueous NaHCO3 and brine
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. customevaporated
8. dry with materialThe crude product was dry
9. custompurified by MPLC (DCM/MeOH 0%-5%)