8-Bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one → HCID 59619845, compound

Participants

Reaction Steps

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A) and 2-(2-methyl-imidazol-1-yl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine (Stage 78.1.1) to give the title compound as a white solid. (HPLC: tR 2.10 min (Method A); M+H=451 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 9.01 (s, 1H), 8.68-8.66 (m, 1H), 8.18-8.13 (m, 2H), 8.09-8.00 (m, 2H), 7.78-7.74 (m, 1H), 7.63-7.59 (m, 2H), 6.94-6.93 (m, 1H), 3.93 (s, 3H), 3.59 (s, 3H), 2.54 (s, 3H), 1.96 (s, 3H))

Provenance & Evidence