2-Methylaminopyrimidine-5-boronic acid, pinacol ester → 1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(2-methylamino-pyrimidin-5-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one

Participants

Reaction Steps

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A) and methyl-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-yl]-amine (Stage 80.1.1) to give the title compound as a white solid. (HPLC: tR 2.18 min (Method A); M+H=401 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 8.93 (s, 1H), 8.49-8.34 (s, br, 2H), 8.13-8.11 (m, 1H), 8.07-8.04 (m, 1H), 7.89-7.85 (m, 1H), 7.42-7.37 (m, 2H), 3.90 (s, 3H), 3.57 (s, 3H), 2.84 (d, 3H), 1.96 (s, 3H))

Provenance & Evidence