2-Aminopyrimidine-5-boronic acid, pinacol ester → HCID 49835615, compound

Participants

Reaction Steps

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A) and 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-ylamine (Combi-Blocks, San Diego, USA) to give the title compound as a white solid. (HPLC: tR 2.04 min (Method A); M+H=387 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 8.93 (s, 1H), 8.37 (s, 2H), 8.14-8.12 (m, 1H), 8.07-8.03 (m, 1H), 7.90-7.86 (m, 1H), 7.41-7.38 (m, 1H), 6.93 (s, br, 2H), 3.91 (s, 3H), 3.57 (s, 3H), 1.95 (s, 3H))

Provenance & Evidence