{2-Fluoro-3-[(propan-2-yl)oxy]phenyl}boronic acid → HCID 59620055, compound

Participants

Reaction Steps

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A) and 2-fluoro-3-isopropoxyphenylboronic acid (Combi-Blocks, San Diego, USA) to give the title compound as a white solid. (HPLC: tR 2.91 min (Method A); M+H=446 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 8.99 (s, 1H), 8.11-8.07 (m, 2H), 7.77-7.73 (m, 1H), 7.56-7.54 (m, 1H), 7.22-7.15 (m, 2H), 6.99-6.92 (m, 1H), 4.64 (hp, 1H), 3.87 (s, 3H), 3.58 (s, 3H), 1.94 (s, 3H), 1.33-1.28 (m, 6H))

Provenance & Evidence