反应详情

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A) and 3-isopropoxy-2-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine (Stage 93.1.1) to give the title compound as a white solid. (HPLC: tR 2.73 min (Method A); M+H=459 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 8.96 (s, 1H), 8.11-8.07 (m, 2H), 7.97-7.93 (m, 1H), 7.92-7.90 (m, 1H), 7.53-7.51 (m, 1H), 7.23-7.21 (m, 1H), 4.70 (hp, 2H), 3.89 (s, 3H), 3.89 (s, 3H), 3.58 (s, 3H), 1.98 (s, 3H), 1.36-1.30 (m, 6H))

1. customThe title compound was synthesized in a similar manner