2-Cyanopyridine-5-boronic acid pinacol ester → 5-[1-(1,3-Dimethyl-1h-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-c]quinolin-8-yl]-pyridine-2-carbonitrile

Participants

Reaction Steps

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A) and 2-cyanopyridine-5-boronic acid pinacol ester (Frontier Scientific, Logan, USA) to give the title compound as a brown solid. (HPLC: tR 2.42 min (Method A); M+H=396 MS-ES)

Provenance & Evidence