3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine → HCID 59619950, compound

Participants

Reaction Steps

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate H) and 3-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-ylamine (stage 142.1.1) to give the title compound as a yellow foam. (HPLC: tR 2.07 min (Method A); M+H=418 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 8.92 (s, 1H), 8.05-8.01 (m, 1H), 7.91-7.84 (m, 2H), 7.47-7.42 (m, 1H), 7.35-7.32 (m, 1H), 6.49 (s, 2H), 3.83 (s, 3H), 3.58 (s, 3H), 2.07 (s, 3H), 1.90 (s, 3H))

Provenance & Evidence