HCID 59613059, compound → HCID 59619676, compound

HRID 445708Notes

Reaction equation

HRID 445708 reaction equation
Br[C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[CH:7][C:6]3[N:12]([CH3:23])[C:13](=[O:22])[N:14]([C:15]4[C:16]([CH3:21])=[N:17][N:18]([CH3:20])[CH:19]=4)[C:5]=3[C:4]=2[CH:3]=1.[C:24]([O:28][C:29]([N:31]([CH2:52][CH3:53])[C:32]1[C:33]([CH2:47][O:48][C:49](=[O:51])[CH3:50])=[N:34][CH:35]=[C:36](B2OC(C)(C)C(C)(C)O2)[CH:37]=1)=[O:30])([CH3:27])([CH3:26])[CH3:25]>>[C:24]([O:28][C:29]([N:31]([CH2:52][CH3:53])[C:32]1[C:33]([CH2:47][O:48][C:49](=[O:51])[CH3:50])=[N:34][CH:35]=[C:36]([C:2]2[CH:11]=[CH:10][C:9]3[N:8]=[CH:7][C:6]4[N:12]([CH3:23])[C:13](=[O:22])[N:14]([C:15]5[C:16]([CH3:21])=[N:17][N:18]([CH3:20])[CH:19]=5)[C:5]=4[C:4]=3[CH:3]=2)[CH:37]=1)=[O:30])([CH3:27])([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 59613059HCID 59613059, compoundHCID 596197398-Bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one2×

Product 1

HCID 59619676HCID 59619676, compound

Procedure

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A, 0.109 mmol) and acetic acid 3-(tert-butoxycarbonyl-ethyl-amino)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-ylmethyl ester (stage 155.1.2) to give the title compound as an off-white solid. (HPLC: tR 2.88 min (Method A); M+H=586 MS-ES)

Workup

  1. customThe title compound was synthesized in a similar manner

Sources & evidence

ORD record
ord-4d6b58b7e5cb4dfe997ab0bad6a134e6
Source dataset
uspto-grants-2013_07
Patent number
US08476294B2

Reaction notes

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