8-Bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one → HCID 49834902, compound

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Reaction Steps

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A) and Cyclobutyl-methyl-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-3-yl]-amine (Stage 174.1.1) to give the title compound as a white solid. (HPLC: tR 2.39 min (Method A); M+H=454 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 8.97 (s, 1H), 8.15-8.04 (m, 4H), 7.96-7.92 (m, 1H), 7.60-7.57 (m, 11-1), 7.06-7.03 (m, 1H), 4.17 (qt, 1H), 3.88 (s, 3H), 3.58 (s, 3H), 2.89 (s, 3H), 2.28-2.02 (m, 4H), 1.97 (s, 3H), 1.81-1.63 (m, 2H))

Provenance & Evidence